Molecular Dynamics and Binding Specificity Analysis of the Bovine Immunodeficiency Virus BIV Tat-TAR Complex
نویسندگان
چکیده
منابع مشابه
Molecular dynamics and binding specificity analysis of the bovine immunodeficiency virus BIV Tat-TAR complex.
We have performed molecular dynamics (MD) simulations, with particle-mesh Ewald, explicit waters, and counterions, and binding specificity analyses using combined molecular mechanics and continuum solvent (MM-PBSA) on the bovine immunodeficiency virus (BIV) Tat peptide-TAR RNA complex. The solution structure for the complex was solved independently by Patel and co-workers and Puglisi and co-wor...
متن کاملMolecular recognition in the bovine immunodeficiency virus Tat peptide-TAR RNA complex.
BACKGROUND In lentiviruses such as human immunodeficiency virus (HIV) and bovine immunodeficiency virus (BIV), the Tat (trans-activating) protein enhances transcription of the viral RNA by complexing to the 5'-end of the transcribed mRNA, at a region known as TAR (the trans-activation response element). Identification of the determinants that account for specific molecular recognition requires ...
متن کاملFlexibility of BIV TAR-Tat: models of peptide binding.
A new approach in determining local residue flexibility from base-amino acid contact frequencies is applied to the twelve million lattice chains modeling BIV Tat peptide binding to TAR RNA fragment. Many of the resulting key features in flexibility correspond to RMSD calculations derived from a set of five NMR derived structures (X. Ye, R. A. Kumar, and D. J. Patel, Protein Data Bank: Database ...
متن کاملSolution structure of a bovine immunodeficiency virus Tat-TAR peptide-RNA complex.
The Tat protein of bovine immunodeficiency virus (BIV) binds to its target RNA, TAR, and activates transcription. A 14-amino acid arginine-rich peptide corresponding to the RNA-binding domain of BIV Tat binds specifically to BIV TAR, and biochemical and in vivo experiments have identified the amino acids and nucleotides required for binding. The solution structure of the RNA-peptide complex has...
متن کاملThe first study of bovine immunodeficiency virus (BIV) and brucellosis co-infection in west-central Iran
Background: BIV is a well-known bovine immunosuppressive cause, but its pathogenesis has not been well characterized. In recent years, it has been hypothesized that infection with BIV might predispose cattle to be infected by other agents. OBJECTIVE: This study was performed to investigate of BIV and Brucella co-infection so that in the future more studies will be done on the issue of predispos...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2001
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(01)76250-9